Pleiotropic mechanisms of action of perhexiline in heart failure
نویسندگان
چکیده
منابع مشابه
The Different Mechanisms of Action Potential Propagation in the Heart
It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
متن کاملThe Different Mechanisms of Action Potential Propagation in the Heart
It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
متن کاملPerhexiline: lessons for heart failure therapeutics.
SEE PAGE 202 I n heart failure with reduced ejection fraction, mechanical work produced by the left ventricle to support the systemic circulation decreases over time despite relatively constant myocardial oxygen consumption. The resulting decrease in the ratio of mechanical work to oxygen consumed, or mechanical efficiency, is a cardinal feature of heart failure (1). Extensive research in exper...
متن کاملthe different mechanisms of action potential propagation in the heart
it was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (ap). it seems that some other types of mechanisms must be involved in ap propagation. in this article, we...
متن کاملMechanisms of carvedilol action in human congestive heart failure.
The precise mechanism by which beta-adrenoceptor blockers exert their beneficial actions in patients with heart failure remains unclear. Several possibilities have been proposed, including heart rate reduction, beta2-adrenoceptor-mediated modulation of catecholamine release, antagonism of the receptor-mediated toxic actions of norepinephrine on the myocardium, and favorable effects on myocardia...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Patents
سال: 2016
ISSN: 1354-3776,1744-7674
DOI: 10.1080/13543776.2016.1211111